Ozone Therapy and EBOO/RHP

Extra-corporeal Blood Oxygenation and Ozonation EBOO Recuiculatory Haemoperfusion RHP is a procedure, which was developed and used in medical departments with the aim of amplifying the results observed with ozone. Relying confidently on the valid principles of ozone therapy, a medical team endeavored to increase its therapeutic efficacy. More than fifteen-years, that team developed an apparatus that makes it possible to treat large quantities of blood with ozone in an extracorporeal circulation.

 The development of EBOO/RHP combines modern membrane hemofiltration used in the treatment of heart, kidney, and liver failure with infusion of therapeutic concentrations of ozone gas into the artificial organ or dialyses. Although ignored by conventional western medicine system, the healing properties of ozone have been known and applied in medical practice in mainland Europe since the beginning of the First World War, where it was applied topically to remedy gangrene and promote wound healing. Extensive investigation on oxidative stress biomarkers and clinical trials are a way to validate this new technique further.

 So it’s shown that “EBOO/RHP” is an infrequent method where the body’s blood is slowly circulated through a machine that ozonates the blood. The blood is then infused back to the body. The whole procedure takes about an hour to complete.

 The EBOO/RHP technique can be easily adapted for use in hemodialysis also. The standard therapeutic cycle lasts for 7 weeks in which 14 treatment sessions of 1 hour are performed. After a session of EBOO/RHP, the interaction of ozone with blood components results in 4–5-fold increased levels of thiobarbituric acid reactants and a proportional decrease in plasma protein thiols without any appreciable erythrocyte haemolysis. On the basis of preliminary in vitro evidence, these simple laboratory parameters may represent a useful complement in the routine monitoring of biological compliance to the treatment. The clinical experience gained so far confirms the great therapeutic potential of EBOO/RHP in patients with severe peripheral arterial disease, coronary disease, cholesterol embolism, severe dyslipidemia, Made lung disease, and sudden deafness of vascular origin. Extensive investigation on oxidative stress biomarkers and clinical trials are under way to validate this new technique further.

 EBOO/RHP is also reported to have remedied necrotic fasciitis, an often-fatal bacterial infection resistant to antibiotics. Ozone's anti-bacterial and viral properties have been employed successfully in water purification. The International Society of Blood Purification has recognized EBOO/RHP as warranting clinical investigation as a reducing treatment. Ozone has been shown to disinfect extracorporeal blood of viruses.

 Oxygenators designed for heart surgery and kidney dialysis may not suitable for EBOO/RHP. Due to the oxidative nature of ozone, the filter components and membranes will block up and inhibit the effective exchange of gas, possibly releasing toxic compounds into the circulating blood. An economical ozone resistant gas exchange device has been specifically designed for the ozonation of human blood during extra-corporeal circulation.

 It is known that there are not many places, which provide the actual EBOO/RHP therapy in which almost all of the blood is assonated in a period of one hour. There are an increasing number of autohemotherapy clinics that provide a partial blood ozonation. However, EBOO/RHP is not yet available in any English speaking countries.

 RHP (Recirculatory Haemoperfusion)


We would like to introduce ourselves as one of the largest ozone centers in Malaysia, First to Provide Ground – Breaking Therapy in the Treatment and Prevention of Coronary Artery Disease.


RHP has set benchmarks, by its self-recognition in playing the key role in the treatment and Prevention of Coronary Artery Disease. No Cardiologist, Medical Professional, or Coronary Heart Disease Patient can afford to ignore the vital role of RHP.


As a leader in the discovery, development, manufacture and marketing of RHP (Recirculatory Haemoperfusion), is committed to improving health and well being through innovative treatments, products and services. We share the medical world's goal of bringing safer and more effective products to the market as promptly as possible.


Before we introduce our treatment, products and services, allow us to give a brief intro of ozone therapy which began in 1870 in Germany and is now recognized in more than 25 countries all around the world including Germany, Italy, Japan, Austria, Switzerland, and some states in the US. It in fact is also approved as a Medical Therapy in Cuba and Russia. There are 2,000 ozone clinics in Europe alone.


The therapeutic use of ozone has an excellent safety record and there have been no toxic effects observed from proper clinical use. The use of ozone as a healing adjunct is well established and is being vigorously pursued by many scientists and clinicians. The benefits are predictable and without any side effects. As technology advances, undoubtedly new techniques will enlarge in the scope of the effective use of this versatile modality.


RHP, the therapeutic ozoniser, an equipment that produces automatically different ozone concentrations in a continuous and reproducible way in all of ozone’s therapeutic range.


It can be used in all ozone medical applications known at present, for example, optic neuropathy, chronic glaucoma, cochleovestibular syndrome, retinitis pigmentosa, senile dementia, sickle cell anemia, sepsis prevention, arthorosis, obliterant arteriopathy, ulcers of the limb, diabetic foot, and radiological contrast in diaphragmatic angiography. In general, in the specialties of ophthalmology, geriatrics, orthopedics, angiology, internal medicine and many more.


RHP is the name of this particular type of ozone generator. As the function implies, RHP generates ozone upon introduction of medical oxygen into generator. Our procedure, known as RHP(Recirculatory Haemoperfusion) is similar to haemodylisis. In this case, RHP is born as a remedy to many cardiological problems, without undergoing the threatening high risk, painful, expensive and complicated procedures of surgery.


Specialized ozone therapy centers, on administrating the non- invasive therapy RHP to severe coronary artery disease patients, have found amazing results which can be supplied on request.


Through years of extensive research, RHP has developed an apparatus called RHP that facilitates in treating 3 to 4 liters of blood with medical ozone in extracorporeal circulation for a period of 60 to 90 minutes to patients with coronary heart disease. RHP has proven to be second to none in delivering its role in this procedural assay. To achieve satisfactory result, one has to undergo 15 to 35 hours therapy depending on the state of the disease or malady.


RHP is performed by withdrawing venous blood and the same blood is infused into an oxygen- ozone gas exchange filter in and upward direction, using a specialized guideline with a computerized peristaltic pump controlling the rate of withdrawal. Medical ozone from RHP is introduced into this hydrophobic and ozone resistant gas exchange filter in the opposite direction from top going downwards as ozonation of blood begins. To avoid coagulation during the process of RHP treatment, slight heparinazation of the blood is done, this just before the blood is infused into the filter. After passing through the oxygen-ozone gas exchange filter, treated blood is then reinfused to the patient. Upon establishment of extracorporeal circuit, the withdrawal rate will be increased to a range of 60-80 ml per minute, depending on the condition of the patient.




It has been established by various scientific researchers that reinfusion of oxygenated and ozonated blood enhances the release of nitric oxide and interleukin-8 in the human endothelial cells (the layer of cells lining the artery wall).


Achieved results of the therapy in general from various conditions show:


1. Improved Vasodilatation (stretching of a vessel/arteriole beyond its normal dimension leading to increased blood flow) in ischemic areas.


2.  Reduced hypoxia (reduction of oxygen carrying capacity of blood)


3.  Induced Neoangiogenesis (formation of new blood vessels) due to enhanced release of nitric oxide.



RHP is a device-based therapy intended to remove extra fluid from the blood and body; Fluid Extraction as the name implies. Patients with heart failure typically are treated with various medications, including angiotensin-converting enzyme inhibitors, beta-blockers, diuretics, and inotropic drugs. Although these drugs don't stop disease progression, they may reduce symptoms and improve functional capacity. Over time, however, some patients stop responding to these therapies.


Fluid Extraction, a process that removes fluid from the intravascular compartment can help ease symptoms for these patients. It may even help patients respond again to conventional drug therapy.  


During Fluid Extraction, the patient intravascular fluid remains stable, as fluid shifts from extravascular space that is lost from the vessels. This reduces edema and third spacing. But because fluid is not removed from the vascular compartment any faster than it can be recruited from the peripheral tissues, patients do not become hypotensive- the plasma refilling rate is adequate to prevent hypovolemia. The patient's heart rate, blood pressure and serum electrolytes also remain largely unchanged.


In general, RHP improves the quality of life with the ceasing of anginal pain and increase of functional abilities. We are proud to say that Fluid Extraction is a truly high quality invention by a team of medical experts and engineers.


We would also like to dedicate our sincere appreciation to the 1998 Nobel Prize Winners in Physiology or Medicine for their discoveries concerning nitric oxide as a signaling molecules in the cardiovascular system- Robert F. Furchgott (SUNY Health Science Center Brooklyn, New York, USA), Louis J. Ignarro (University of California School of Medicine) and Ferid Murad (University of Texas) for their discoveries concerning the role of nitric oxide as a signaling molecule in the cardiovascular system. These medical experts have given us the inspiration and encouragement to come up with our invention RHP (Recirculatory Haemoperfusion).


We will be more than happy to assist you in any way possible, either a request for demonstration or merely further queries. Our medical counselors are available daily (except public holidays) for assistance and to answer questions. Research papers are available on demand and we will be glad to provide a more-detailed explanation of the procedures and other related matters.


Please do no hesitate to contact us at:






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